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Irbesartan and Hydrochlorothiazide tablets are contraindicated in patients who are hypersensitive to any component of the products. As a result of hydrochlorothiazide ingredient, this product or service is contraindicated in sufferers with anuria or hypersensitivity to other sulfonamide-derived medications.
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Irbesartan isn't going to inhibit ACE or renin or affect other hormone receptors or ion channels recognized for being involved with the cardiovascular regulation of hypertension and sodium homeostasis.
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Blockade on arena plus the AT1 receptor eliminates the adverse feed-back of angiotensin II on renin secretion, however the ensuing elevated plasma renin exercise and circulating angiotensin II never triumph over the results of irbesartan on blood pressure.
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